Alpheus Medical Raises $52M Series B to Advance Non-Thermal Brain Cancer Therapy

Alpheus Medical is a clinical-stage oncology company advancing an innovative platform that leverages ultrasound to activate cancer-targeting compounds.

Alpheus Medical Raises $52M Series B to Advance Non-Thermal Brain Cancer Therapy
Source: Alpheus Medical

Company Name: Alpheus Medical
Location: Chanhassen, MN
Industry: Health Tech

Funding Details:

  • Amount: $52M
  • Round: Series B
  • Investors:
    • Lead: HealthQuest Capital, Samsara BioCapital
    • Participants: OrbiMed, Action Potential Venture Capital, BrightEdge, Brain Tumor Investment Fund, Sontag Innovation Fund

Purpose of Investment:
To support a Phase 2B randomized controlled trial (RCT) evaluating the efficacy of sonodynamic therapy (SDT) in patients with newly diagnosed glioblastoma (GBM).

Leadership:

  • President & CEO: Vijay Agarwal, MD, FAANS, FCNS

Product:
Alpheus Medical is developing a novel, non-thermal, tumor-selective treatment for glioblastoma using:

  • Low-intensity diffuse ultrasound (LIDU)
  • Oral 5-aminolevulinic acid (5-ALA)

This therapy:

  • Selectively targets and destroys cancer cells across the brain hemisphere
  • Requires no imaging or sedation
  • Is delivered in an outpatient setting

About Company:
Alpheus Medical is a clinical-stage oncology company advancing an innovative platform that leverages ultrasound to activate cancer-targeting compounds. Its approach aims to offer a less invasive, outpatient alternative to conventional brain cancer therapies, addressing an urgent unmet need in glioblastoma treatment.