AI Investor Tracker

a16z’s AI Portfolio: Startups Backed by Andreessen Horowitz (2026 Tracker)

Andreessen Horowitz (a16z) is one of the most aggressive backers in the AI space. See which AI startups they've funded - and the verticals they’re doubling down on.

a16z’s AI Portfolio: Startups Backed by Andreessen Horowitz (2026 Tracker)
Source: a16z
Last updated: January, 2026


This tracker covers the top artificial intelligence startups funded by a16z in 2025. From chips to copilots, foundation models to open-source tooling, Andreessen Horowitz is everywhere AI is heating up.

🧠 About a16z & Their AI Thesis

From foundational bets like OpenAI (way back when) to leading late-stage rounds for next-gen platforms, the firm has made AI central to its strategy.

Marc Andreessen’s famous “Software is eating the world” now has a sequel: “AI is eating software.”

Category Notable Startup Latest Deal Trend Insight
Foundation Models / GenAI Thinking Machines Lab ~$2B (2025) a16z leads mega-rounds even pre-product, signaling conviction in new AI giants
Developer Copilots (Vertical AI) Cursor $625M (Feb 2025) Expert-facing copilots scale faster than horizontal tools
Legal AI Copilots Harvey $300M Series D (2025) Vertical AI wins in high-stakes, high-ROI workflows
AI Hardware & Infrastructure Groq $640M Series D (Aug 2024) a16z is backing chips to challenge Nvidia’s dominance
Voice & Interface Layer ElevenLabs $180M (2025) Voice + multimodal is emerging as the next-gen AI interface
Healthcare AI Agents Hippocratic AI $141M Series B (2025) Trust-first AI agents unlock regulated healthcare adoption
Clinical Workflow Automation Ambience Healthcare $243M Series C (2025) Clinical documentation + coding automation is scaling fast
Clinical Workflow Automation Abridge $150M (2025) Hospital operations represent a trillion-dollar automation opportunity
Customer Experience AI Agents Decagon $45M (2025) AI agents reduce CX costs while improving service quality
Creative AI / Video Hedra $32M Series A (2025) Omnimodal characters push AI deeper into creator infrastructure
Interactive Media AI Rumi Labs $4.7M Pre-Seed (2025) Early bets on AI-native interactive entertainment
Logistics AI HappyRobot $44M Series B (2025) AI agents are infiltrating freight and logistics operations
Prosumer Performance AI Cluely $15M (2025) “AI superpowers” thrive via viral, bottom-up adoption
Enterprise AI Search Glean $150M Series F (2025) Enterprise search is becoming an always-on AI workflow layer
Customer Support AI Agents Sierra Undisclosed (2024–2025) Bret Taylor–led bet on autonomous enterprise support agents
AI Infrastructure / Routing OpenRouter $40M Series A (2025) Middleware layer for routing across LLMs and cloud providers
AI Search Visibility Profound $35M Series B (2025) Optimizing brand presence in AI-native search engines
Accounting & Finance AI Rillet $70M Series B (2025) AI quietly replaces back-office finance workflows
Deals pulled from SEC filings + press releases.
Know a startup we missed? or an unannounced a16z AI term sheet? Give us a tip to get it added: Email us

Top a16z-Backed AI Startups (2025)

1. Thinking Machines Lab

  • Round: ~$2B (2025)
  • Valuation: $12B
  • Sector: Foundation Models / GenAI
  • What They Do: Early-stage AI lab led by ex–OpenAI CTO Mira Murati.
  • Why It Matters: Massive raise pre-product. a16z is betting on new AI giants from day one.

2. Cursor

  • Round: $625M (Feb 2025)
  • Valuation: $9.6B
  • Sector: AI Copilot for Developers
  • What They Do: A natural language interface for writing, refactoring, and debugging code
  • Why It Matters: a16z joined Thrive as a lead. Cursor is becoming the go-to dev tool for AI-powered coding, making it one of the highest-valued vertical copilots in the space.

3. Groq

  • Round: $640M Series D (Aug 2024)
  • Valuation: $2.8B
  • Sector: AI Chips / Hardware
  • What They Do: Building custom AI chips and hardware optimized for LLM inference
  • Why It Matters: Co-led by a16z and BlackRock. Groq is one of the few companies tackling the GPU bottleneck head-on with next-gen silicon.

4. ElevenLabs

  • Round: $180M (2025)
  • Sector: Voice AI / GenAI
  • What They Do: AI-powered speech synthesis and voice cloning
  • Why It Matters: a16z co-led this round. Voice is fast becoming a key interface, and ElevenLabs is leading the charge with creator-ready tools and enterprise-grade accuracy.

5. Hippocratic AI

  • Round: $141M Series B (2025)
  • Sector: Healthcare AI Agents
  • What They Do: Safe, non-diagnostic AI agents for patient-facing use cases
  • Why It Matters: a16z is a participating investor. Their involvement in Hippocratic highlights growing conviction in high-trust, regulated AI applications — especially in healthcare.

6. Harvey

  • Round: $300M Series D (2025)
  • Sector: Legal AI / Enterprise
  • What They Do: AI co-pilot for lawyers
  • Why It Matters: a16z joined other top-tier funds like Sequoia and Kleiner Perkins. This signals a16z’s belief in vertical copilots, especially in high-stakes industries like law.

7. Ambience Healthcare

  • Round: $243M Series C (2025)
  • Sector: Healthcare AI / Medical Scribe
  • What They Do: Ambient transcription + coding automation across 40+ health systems.
  • Why It Matters: a16z doubling down on regulated healthcare AI with enterprise adoption.

8. Hedra

  • Round: $32M Series A (2025)
  • Sector: Creative AI / Video Characters
  • What They Do: Omnimodal character models animating video, audio & images.
  • Why It Matters: a16z’s push into AI-powered creator infrastructure.

9. Glean

  • Round: $150M Series F (2025)
  • Valuation: $7.2B
  • Sector: Enterprise AI Search
  • What They Do: Agentic enterprise search that proactively surfaces knowledge and automates workflows across teams.
  • Why It Matters: a16z is betting that search becomes an always-on AI layer embedded inside enterprise operations.

10. Sierra

  • Round: Early-stage (2024–2025)
  • Sector: Customer Experience AI Agents
  • What They Do: Autonomous AI agents designed to resolve customer support issues end-to-end.
  • Why It Matters: Signals a shift from copilots to full agents in customer-facing enterprise workflows.

11. OpenRouter

  • Round: $40M Series A (2025)
  • Sector: AI Infrastructure / LLM Connectivity
  • What They Do: Unified API that routes AI apps across multiple LLMs and cloud providers.
  • Why It Matters: Infrastructure leverage play as teams avoid vendor lock-in and optimize performance and cost.

12. Profound

  • Round: $35M Series B (2025)
  • Sector: AI Search Visibility / Marketing
  • What They Do: Helps brands optimize how they appear in AI-driven search and answer engines.
  • Why It Matters: a16z is positioning for the economics of attention in an AI-native search world.

13. Rillet

  • Round: $70M Series B (2025)
  • Sector: FinTech / AI Accounting
  • What They Do: Automates accounting workflows and ledgers using AI.
  • Why It Matters: Reinforces a16z’s thesis that AI quietly replaces back-office systems before flashy front-end apps.

a16z’s AI Strategy Signals

  • 🏥 Healthcare is the new dev-tools → Ambience, Hippocratic, Abridge, Tennr.
  • 💸 Big, bold bets → From $2B pre-product raises to $600M+ growth rounds.
  • 🔗 Stack coverage → Chips (Groq) → Apps (Cursor, Harvey) → Interfaces (ElevenLabs) → Verticals (Ambience, HappyRobot).
  • 🎬 Beyond SaaS → New wagers in creative AI (Hedra) + interactive media (Rumi Labs).
  • 📈 2025 funding mix → 40% healthcare, 25% infra, 20% vertical copilots, 15% entertainment/logistics
  • 🤖 From copilots → agents: Sierra, Glean, and Decagon show a pivot toward autonomous AI systems.
  • 🧱 Middleware matters: OpenRouter and Profound highlight growing investment in the invisible layers powering AI adoption.

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